郭順宇｜Kuo, Shun-Yu

郭順宇｜Kuo, Shun-Yu

🎓　專任教授

👨‍🎓　國立清華大學

　　輻射生物研究所博士

📞　07-7811151 轉 5413

📧　mt100@fy.edu.tw

📖　學術專長

天然物活性研究、人體生理學、訊號傳遞、生物化學

學歷

國立清華大學輻射生物研究所哲學博士(1998)
國立清華大學輻射生物研究所碩士(1990)
私立天主教輔仁大學生物系學士(1988)

經歷

輔英科技大學 /醫學與健康學院祕書(08/01/2008~07/31/2016)
國立清華大學生命科學系博士後研究(08/01/1998-07/31/2000)
中央研究院植物研究所/研究助理(郭宗德院士實驗室，08/01/1992-07/31/1993

學術專長

訊號傳遞
生物化學
癌症與化學預防
天然物活性分析

專題/論文指導

104 學年度專題: Enhancement of cisplatin cytotoxicity by diallyl disulfide in human oral cancer cells，簡怡萍。
104 學年度專題: Cisplatin in combination with Phenethyl Isothiocyanate (PEITC), a potential therapeutic Strategy for Oral Squamous Cell Carcinoma. 鄭敬憫。
104 學年度專題: Cisplatin in combination with Allyl Isothiocyanate (AITC), a potential therapeutic Strategy for Oral Squamous Cell Carcinoma.，梁敬杰。
107 學年度專題:Effect of hexahydrocrucumin on degranulation and Inflammatory Mediator Release in RBL-2H3 cells，邵至謙、洪祥毓。
108 學年度專題: Phenylethyl isothiocyanate inhibits proliferation and induces apoptosis in human oral cancer cells，周庭瑜; The Toxic Effect of benzyl isothiocyanate on RBL-2H3 Cells，吳承庭
110 學年度專題: Efficacy of PEITC Combined with Cisplatin in Enhance the Death of Human Oral Cancer Cells(SAS)，黃慧菁，洪儷霞
112 學年度專題: Effect of Phenylethyl Isothiocyanate on Intracellular Calcium Levels and Viability in Jurkat Cells，張勛傑
113 學年度專題:
Effect of Benzyl Isothiocyanate on Intracellular Calcium Levels and Viability in Jurkat E6 Cells，黃子綺;
Using RNA sequencing with bioinformatics to analyze Endoplasmic Reticulum Stress by celastrol in SAS tongue cancer cells，潘家成;
Effect of Celastrol on Intracellular Calcium Levels in Jurkat Cells，王苡驊
114 學年度專題:
Mechanism of Celastrol-Induced Oxidative Stress in Jurkat Cells，楊心萍;
Investigation of PEITC-Induced Oxidative Stress and Its Molecular Regulatory Mechanism in Jurkat Cells，蔡閔如

證照

有機溶劑作業主管證照 (勞安管有機字第 18211號)
PVQC (Professional Vocabulary Quotient Credential Programs. Valid from Oct 9, 2023 to Oct 9, 2029)

期刊論文

跟著名偵探思考的通識教育「新」課程--以輔英科技大學「柯南推理與邏輯運用」課程為例. 郭順宇高雄文化研究, 2021.
Tzeng YT, Liu PF, Li JY, Liu LF, Kuo SY, Hsieh CW, Lee CH, Wu CH, Hsiao M, Chang HT, Shu CW. Kinome-Wide siRNA Screening Identifies Src-Enhanced Resistance of Chemotherapeutic Drugs in Triple-Negative Breast Cancer Cells. Front Pharmacol. 2018 9:1285. doi: 10.3389
Shu, C.W., Chang, H.T., Wu, C.S., Chen, C.H., Wu, S., Chang, H.W., Kuo, S.Y., Fu, E., Liu, P.F., Hsieh, Y.D. RelA-Mediated BECN1 Expression Is Required for Reactive OxygenSpecies-Induced Autophagy in Oral Cancer Cells Exposed to Low-Power Laser Irradiation. PLoS One. 2016 11(9):e0160586. doi:10.1371/journal.pone.0160586.
Kuo, S.Y., Chou, M.C., Lee, S.L., Wang, Y., Chen, C.L., Lin, P.T., Lo, H.R. (2015) Vibrio vulnificus RtxA1 modulated calcium flux contributes reduced internalization in phagocytes. Life Sci. 132:55-60. doi: 10.1016/j.lfs.2015.03.027.
Liu, F.J., Chou, C.T., Cheng, J.S., Chang, H.T., Liang, W.Z., Kuo, C.C., Kuo, S.Y., Kuo, D.H., Shieh, P., Chang, F.R., Jan, C.R. (2015) Ca2+ movement and apoptosis induced by deltamethrin in Madin-Darby canine kidney canine renal tubular cells. Kaohsiung J Med Sci. 31:1-8. doi: 10.1016/j.kjms.2014.10.009.
Chien, J.M., Chou, C.T., Liang, W.Z., Cheng, J.S., Chang, H.T., Tseng, H.W., Kuo, S.Y., Kuo, C.C., Chen, F.A., Shieh, P., Ho, C.M., Lin, J.R., Kuo, D.H., Jan, C.R. (2014) Effect of deoxycholic acid on Ca2+ movement, cell viability and apoptosis in human gastric cancer cells. Toxicol Mech Methods. 19:1-20.

研討會論文

Ching-Ju Hsu, Zih-Ci Huang, Yi-Hua Wang, Jia-Cheng Pan, Hsun-Chieh Cheng, Soong-Yu Kuo*. (2024) Effect of Benzyl Isothiocyanate on Intracellular Calcium Levels and Viability in Jurkat E6 Cells. Cross-strait Lab. Med. Sym. 2024 Oct 12-13, Taipei (ROC), C041.
Jia-Cheng Pan, Yi-Hua Wang, Zih-Ci Huang, Hsun-Chieh Cheng, Soong-Yu Kuo*. (2024) Using RNA sequencing with bioinformatics to analyze Endoplasmic Reticulum Stress by celastrol in SAS tongue cancer cells. Cross-strait Lab. Med. Sym. 2024 Oct 12-13, Taipei (ROC), C021.
Kuan-Hua Chen, Pei-Feng Liu, Kai -Yang Huang, Soong-Yu Kuo*. The Potential Effects of Celastrol on Oral Cancer Cells-Approaching with Next-Generation Sequencing and Bioinformatics. The 15th Asia-Pacific Forum of Medical Laboratory Science. (2024) Apr 20-21, Kaosiung (ROC), H018.
Hsun-Chieh Chang, Yi-Hua Wang, Zib-Ci Huang, Soong-Yu Kuo*. Investigation of PEITC-Induced Endoplasmic Reticulum Stress and Apoptosis in Jurkat Cells. The 15th Asia-Pacific Forum of Medical Laboratory Science. (2024) Apr 20-21, Kaosiung (ROC), H023.
Ben-Chih Yuan, Yi-Hua Wang, Shiao-Ping Huang , Soong-Yu Kuo*. (2023) Effect of Celastrol on IgE-Mediated Allergic Response in RBL-2H3 Cells. Cross-strait Lab. Med. Sym. 2023 Dec 16-17, Taipei (ROC), C029.
Chia-Lin Cheng, Hsun-Chieh Cheng, Chich-Yu Chang, Zib-Ci Huang, Soong-Yu Kuo*. (2023) Effect of Phenylethyl Isothiocyanate on Intracellular Calcium Levels and Viability in Jurkat Cells. Cross-strait Lab. Med. Sym. 2023 Dec 16-17, Taipei (ROC), C034.
Hui-Jing Huang^#, Li-Xia Hong , Ting-Yu Chou , Chi-Liang Chern , Soong-Yu Kuo*. (2021) Phenylethyl isothiocyanate inhibits proliferation and induces apoptosis in human oral cancer cells. Cross-strait Lab. Med. Sym. 2021 Dec 18-19, Taipei (ROC), C029.
跟著名偵探思考的通識教育「新」課程-以輔英科技大學「柯南推理與邏輯運用」課程為例 2021年歷史與文化暨通識教育學術研討會
Yuan, B-C, Shao, C-C, Hung, S-Y, Zhang, Y-C, Huang, S-P, Chen, C-Y, Kuo, S.-Y.# (2019) Effect of hexahydrocrucumin on degranulation and Inflammatory Mediator Release in RBL-2H3 cells. The 34 th Joint Ann. Conf. Biomed. Sci. Mar 23-24, Taipei (ROC), BC161.
Lee, P.-H., Chang, C.-T., Chen, J.-Y., Kuo, S.-Y.# (2018) Effect of Celastrol on Cytosolic Ca2+ Levels and Proliferation in Human Oral Cancer Cells (SAS). The 33 th Joint Ann. Conf. Biomed. Sci. Mar 24-25, Taipei (ROC), BC095.
Cheng, C.-M., Liang, C.-C., Jian, Y.-P., Chen, J.-Y., Kuo, S.-Y.# (2016) Cisplatin in Combination with Phenethyl Isothiocyanate (PEITC), a Potential Therapeutic Strategy for Oral Squamous Cell Carcinoma. The 31th Joint Ann. Conf. Biomed. Sci. Mar 26-27, Taipei (ROC).
Liang, C.-C., Cheng, C.-M., Jian, Y.-P., Chen, J.-Y., Kuo, S.-Y.# (2016) Cisplatin in Combination with Allyl Isothiocyanate (AITC), a Potential Therapeutic Strategy for Oral Squamous Cell Carcinoma. The 31th Joint Ann. Conf. Biomed. Sci. Mar 26-27, Taipei (ROC).
Jian, Y.-P. Liang, C.-C., Cheng, C.-M., , Chen, J.-Y., Kuo, S.-Y.# (2016) Cisplatin in Combination with Diallyl Disulfide (DADS), a Potential Therapeutic Strategy for Oral Squamous Cell Carcinoma. The 31th Joint Ann. Conf. Biomed. Sci. Mar 26-27, Taipei (ROC).

研究計畫

臨床案例融入生理學教學以提升學生的學習成效(PMN1142120, 2025-08-01 ~ 2026-07-31,主持人) 教育部
運用概念圖教學提升學生對生理學核心概念的學習與遷移(PMN1136699, 2024-08-01 ~ 2025-07-31,主持人) 教育部
差異化教學提升學生有效學習-以人體生理學為例(PMN1121408, 2023-08-01 ~ 2024-07-31,主持人) 教育部
運用「形成性評量」與「圖像式學習」提升學生學習動機-以人體生理學為例(PMN1110198, 2022-08-01 ~ 2023-07-31,主持人) 教育部
運用HiTeach平台支援5E探究學習:以醫技科一年級生物實驗(一)為例(FYU-1008-114-04, 2025-02-19~ 2025-11-15,主持人) 輔英科技大學
設計思考置入課程之應用:以實驗室教學實務(二)為例(FYU-1008-113-09, 2024-01-01~ 2024-11-15,主持人) 輔英科技大學
雷公藤紅素(celastrol)對T細胞急性淋巴細胞白血病細胞之影響(PTVGH-11432, 2025.01.01~2025.12.31,主持人) 屏東榮民總醫院
十字花科蔬菜中異硫氰酸芐酯(BITC)成份對T細胞急性淋巴細胞白血病細胞之影響(PTVGH-E-11302, 2024.01.01~2024.12.31,主持人) 屏東榮民總醫院
十字花科蔬菜中異硫氰酸苯乙酯(PEITC)成份對T細胞急性淋巴細胞白血病細胞之影響(FH-HR- 111 – 17, 2022.08.01~2023.07.31,主持人) 輔英附設醫院
利用RNA序列和生物資訊學的綜合方法分析Celastrol調節SAS舌癌細胞轉錄基因變化的綜合分析(FYU-1300-113-04, 2024.05.01~2024.10.31,主持人) 輔英科技大學
利用RNA序列和生物資訊學的綜合方法分析PEITC調節Jurkat細胞轉錄基因變化(FYU-1300-114-08, 2025.05.01~2025.10.31,主持人) 輔英科技大學
Celastrol對口腔癌細胞遷移與侵襲的影響效(FYU-1300-111-08, 2022.05.01~2022.10.31,主持人) 輔英科技大學
PEITC結合cisplatin對人類口腔癌細胞之功效(FYU-1300-110-10, 2021.05.01~2021.10.31,主持人) 輔英科技大學
Celastrol引發細胞凋亡機制之探討(FYU-1300-109-08, 2020.05.01~2020.10.31,主持人) 輔英科技大學
106學年度就業學程計畫：新興檢驗醫學人才學程(FY106-AA-014, 2017/07/01~2018/08/31,主持人) 勞動部
雷公藤紅素(Celastrol)對人類口腔癌細胞之影響-II( 2019/01/01~2019/12/31,共同主持人) 阮綜合醫療社團法人阮綜合醫院
雷公藤紅素(Celastrol)對人類口腔癌細胞之影響(AI- 106025, 2018/01/01~2018/12/31,共同主持人) 阮綜合醫療社團法人阮綜合醫院
雷公藤紅素對對肥大細胞內IgE媒介過敏發炎機制之探討(FH-HR-107-10, 2018/07/01~2019/08/31,共同主持人) 校院(輔英附設醫院)合作計畫
生薑中非揮發性辛辣成份對肥大細胞內IgE媒介過敏發炎機制之探討(FH-HR-106-08, 2017/07/01~2018/08/31,共同主持人) 校院(輔英附設醫院)合作計畫
十字花科BITC 引發口腔癌細胞凋亡作用機轉之研究(FYU1300-104-04 ,2015.04.01~2015.11.30,主持人) 輔英科技大學。
BITC 誘發口腔癌細胞細胞凋亡及開發口腔癌輔助療法應用之機轉探討(MOST 103-2320-B-242 -003 -, 2014.08.01~2015.7.31,主持人) 科技部。
PETIC 引發細胞鈣離子傳訊及活度之影響(FYU1300-103-16, 2015.04.01~2015.11.30,主持人) 輔英科技大學。

專利

陳中一、郭順宇、陳振臺 “具有口腔癌療效之神秘果萃取物的製備方法及神秘果萃取物用於製備治療口腔癌藥物之用途”, 中華民國,專利號碼：I 546089,專利期間：2016/08/1至2031/01/31, 立特克生物科技股份有限公司。
陳中一、郭順宇、楊偉伶、林雍智陳振臺 “生薑萃取物於抑制大腸癌細胞生長與細胞週期性之用”, 中華民國,專利號碼：I439281,專利期間：2014/06/1至2031/09/30, 立特克生物科技股份有限公司。

榮譽事蹟

104年度教育部大專院校實施特殊優秀人才彈性薪資方案(研究類)
105年度教育部大專院校實施特殊優秀人才彈性薪資方案(研究類)

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