郭順宇｜Kuo, Shun-Yu

郭順宇｜Kuo, Shun-Yu

🎓　專任教授兼研發處組長

👨‍🎓　國立清華大學

　　輻射生物研究所博士

📞　07-7811151 轉 5413

📧　mt100@fy.edu.tw

📖　學術專長

天然物活性研究、人體生理學、訊號傳遞、生物化學

學歷

經歷

學術專長

專題/論文指導

104 學年度專題: Enhancement of cisplatin cytotoxicity by diallyl disulfide in human oral cancer cells，簡怡萍。
104 學年度專題: Cisplatin in combination with Phenethyl Isothiocyanate (PEITC), a potential therapeutic Strategy for Oral Squamous Cell Carcinoma. 鄭敬憫。
104 學年度專題: Cisplatin in combination with Allyl Isothiocyanate (AITC), a potential therapeutic Strategy for Oral Squamous Cell Carcinoma.，梁敬杰。
107 學年度專題:Effect of hexahydrocrucumin on degranulation and Inflammatory Mediator Release in RBL-2H3 cells，邵至謙、洪祥毓。

證照

期刊論文

Tzeng YT, Liu PF, Li JY, Liu LF, Kuo SY, Hsieh CW, Lee CH, Wu CH, Hsiao M, Chang HT, Shu CW. Kinome-Wide siRNA Screening Identifies Src-Enhanced Resistance of Chemotherapeutic Drugs in Triple-Negative Breast Cancer Cells. Front Pharmacol. 2018 9:1285. doi: 10.3389
Shu, C.W., Chang, H.T., Wu, C.S., Chen, C.H., Wu, S., Chang, H.W., Kuo, S.Y., Fu, E., Liu, P.F., Hsieh, Y.D. RelA-Mediated BECN1 Expression Is Required for Reactive OxygenSpecies-Induced Autophagy in Oral Cancer Cells Exposed to Low-Power Laser Irradiation. PLoS One. 2016 11(9):e0160586. doi:10.1371/journal.pone.0160586.
Kuo, S.Y., Chou, M.C., Lee, S.L., Wang, Y., Chen, C.L., Lin, P.T., Lo, H.R. (2015) Vibrio vulnificus RtxA1 modulated calcium flux contributes reduced internalization in phagocytes. Life Sci. 132:55-60. doi: 10.1016/j.lfs.2015.03.027.
Liu, F.J., Chou, C.T., Cheng, J.S., Chang, H.T., Liang, W.Z., Kuo, C.C., Kuo, S.Y., Kuo, D.H., Shieh, P., Chang, F.R., Jan, C.R. (2015) Ca2+ movement and apoptosis induced by deltamethrin in Madin-Darby canine kidney canine renal tubular cells. Kaohsiung J Med Sci. 31:1-8. doi: 10.1016/j.kjms.2014.10.009.
Chien, J.M., Chou, C.T., Liang, W.Z., Cheng, J.S., Chang, H.T., Tseng, H.W., Kuo, S.Y., Kuo, C.C., Chen, F.A., Shieh, P., Ho, C.M., Lin, J.R., Kuo, D.H., Jan, C.R. (2014) Effect of deoxycholic acid on Ca2+ movement, cell viability and apoptosis in human gastric cancer cells. Toxicol Mech Methods. 19:1-20.

研討會論文

Yuan, B-C, Shao, C-C, Hung, S-Y, Zhang, Y-C, Huang, S-P, Chen, C-Y, Kuo, S.-Y.# (2019) Effect of hexahydrocrucumin on degranulation and Inflammatory Mediator Release in RBL-2H3 cells. The 34 th Joint Ann. Conf. Biomed. Sci. Mar 23-24, Taipei (ROC), BC161.
Lee, P.-H., Chang, C.-T., Chen, J.-Y., Kuo, S.-Y.# (2018) Effect of Celastrol on Cytosolic Ca2+ Levels and Proliferation in Human Oral Cancer Cells (SAS). The 33 th Joint Ann. Conf. Biomed. Sci. Mar 24-25, Taipei (ROC), BC095.
Cheng, C.-M., Liang, C.-C., Jian, Y.-P., Chen, J.-Y., Kuo, S.-Y.# (2016) Cisplatin in Combination with Phenethyl Isothiocyanate (PEITC), a Potential Therapeutic Strategy for Oral Squamous Cell Carcinoma. The 31th Joint Ann. Conf. Biomed. Sci. Mar 26-27, Taipei (ROC).
Liang, C.-C., Cheng, C.-M., Jian, Y.-P., Chen, J.-Y., Kuo, S.-Y.# (2016) Cisplatin in Combination with Allyl Isothiocyanate (AITC), a Potential Therapeutic Strategy for Oral Squamous Cell Carcinoma. The 31th Joint Ann. Conf. Biomed. Sci. Mar 26-27, Taipei (ROC).
Jian, Y.-P. Liang, C.-C., Cheng, C.-M., , Chen, J.-Y., Kuo, S.-Y.# (2016) Cisplatin in Combination with Diallyl Disulfide (DADS), a Potential Therapeutic Strategy for Oral Squamous Cell Carcinoma. The 31th Joint Ann. Conf. Biomed. Sci. Mar 26-27, Taipei (ROC).

研究計畫

106學年度就業學程計畫：新興檢驗醫學人才學程(FY106-AA-014, 2017/07/01~2018/08/31,主持人) 勞動部
雷公藤紅素(Celastrol)對人類口腔癌細胞之影響-II( 2019/01/01~2019/12/31,共同主持人) 阮綜合醫療社團法人阮綜合醫院
雷公藤紅素(Celastrol)對人類口腔癌細胞之影響(AI- 106025, 2018/01/01~2018/12/31,共同主持人) 阮綜合醫療社團法人阮綜合醫院
雷公藤紅素對對肥大細胞內IgE媒介過敏發炎機制之探討(FH-HR-107-10, 2018/07/01~2019/08/31,共同主持人) 校院(輔英附設醫院)合作計畫
生薑中非揮發性辛辣成份對肥大細胞內IgE媒介過敏發炎機制之探討(FH-HR-106-08, 2017/07/01~2018/08/31,共同主持人) 校院(輔英附設醫院)合作計畫
十字花科BITC 引發口腔癌細胞凋亡作用機轉之研究(FYU1300-104-04 ,2015.04.01~2015.11.30,主持人) 輔英科技大學。
BITC 誘發口腔癌細胞細胞凋亡及開發口腔癌輔助療法應用之機轉探討(MOST 103-2320-B-242 -003 -, 2014.08.01~2015.7.31,主持人) 科技部。
PETIC 引發細胞鈣離子傳訊及活度之影響(FYU1300-103-16, 2015.04.01~2015.11.30,主持人) 輔英科技大學。

專利

陳中一、郭順宇、陳振臺 “具有口腔癌療效之神秘果萃取物的製備方法及神秘果萃取物用於製備治療口腔癌藥物之用途”, 中華民國,專利號碼：I 546089,專利期間：2016/08/1至2031/01/31, 立特克生物科技股份有限公司。
陳中一、郭順宇、楊偉伶、林雍智陳振臺 “生薑萃取物於抑制大腸癌細胞生長與細胞週期性之用”, 中華民國,專利號碼：I439281,專利期間：2014/06/1至2031/09/30, 立特克生物科技股份有限公司。

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