黃美涵｜Huang, Mei-Han
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黃美涵｜Huang, Mei-Han
🎓 專任助理教授
👨🎓 高雄醫學大學
生物化學所碩士
📞 07-7811151 轉 7595
📧 hmhmhtw8@gmail.com
📖 學術專長
臨床生理、濫用藥物
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學歷
- 高雄醫學大學 生物化學所碩士
- 高雄醫學大學 醫技系
經歷
- 輔英科技大學 /醫技系 /助理教授
- 高雄醫學大學/生物化學 /助教
學術專長
- 質譜分析與濫用藥物研究
- 臨床生理
專題/論文指導
- 102學年度專題:Methadone and Its Main Metabolite EDDP Concentration in Oral Fluid and Whole Blood Correlation by Gas Chromatography -Mass Spectrometry (GC-MS) Kai-Wen Li, Yu-Shan Zhang, Ya-Ching Hsu, Wei-Hsi Chen, Yi-Ching Li, Bo-Han Tseng
- 102學年度專題:Effects of methadone on human kidney cell， 102學年度專題: Methadone and Its Main Metabolite EDDP Concentration in Plasma and Whole Blood Correlation by Gas Chromatography-Mass Spectrometry Yu-Shan Zhang, Kai-Wen Li, Ya-Ching Hsu, Wei-Hsi Chen, Yi-Ching Li, Bo-Han Tseng
- 104學年度專題:Effects of Codeine and its metabolite on human kidney cell, human colon cancer cell and PBMCs
證照
- 醫事檢驗師
期刊論文
- Characterization of Perturbing Actions by Verteporfin, a Benzoporphyrin Photosensitizer, on Membrane Ionic Currents. Huang MH, Liu PY, Wu SN. Front Chem. 2019 Aug 22;7:566. doi: 10.3389/fchem.2019.00566. eCollection 2019. PMID: 31508407
- Epigallocatechin-3-Gallate Suppresses Human Herpesvirus 8 Replication and Induces ROS Leading to Apoptosis and Autophagy in Primary Effusion Lymphoma Cells. Tsai CY, Chen CY, Chiou YH, Shyu HW, Lin KH, Chou MC, Huang MH, Wang YF. Int J Mol Sci. 2017 Dec 21;19(1). pii: E16. doi: 10.3390/ijms19010016.
- The Inhibition by Oxaliplatin, a Platinum-Based Anti-Neoplastic Agent, of the Activity of Intermediate-Conductance Ca²⁺-Activated K⁺ Channels in Human Glioma Cells. Huang MH, Huang YM, Wu SN.
- Cell Physiol Biochem. 2015;37(4):1390-406. doi: 10.1159/000430404. Epub 2015 Oct 22.
- Direct Injection LC-MS-MS Analysis of Opiates, Methamphetamine, Buprenorphine, Methadone and Their Metabolites in Oral Fluid from Substitution Therapy Patients.
- Liu HC, Lee HT, Hsu YC, Huang MH, Liu RH, Chen TJ, Lin DL.J Anal Toxicol. 2015 Jul-Aug;39(6):472-80. doi: 10.1093/jat/bkv041. Epub 2015 May 2
- Effects of ketamine and its metabolites on ion currents in differentiated hippocampal H19-7 neuronal cells and in HEK293T cells transfected with α-hslo subunit. Huang MH, Lin KH, Chen SJ, Shen AY, Wu FT, Wu SN. Neurotoxicology. 2012 Oct;33(5):1058-66.
- Methadone concentrations in blood, plasma, and oral fluid determined by isotope-dilution gas chromatography-mass spectrometry.
- Hsu YC, Chen BG, Yang SC, Wang YS, Huang SP, Huang MH, Chen TJ, Liu HC, Lin DL, Liu RH, Jones AW.
- Anal Bioanal Chem. 2013 May;405(12):3921-8. doi: 10.1007/s00216-012-6460-2. Epub 2012 Oct 23.
- Inhibitory action of methadone and its metabolites on erg-mediated K+ current in GH₃ pituitary tumor cells.
- Huang MH, Shen AY, Wang TS, Wu HM, Kang YF, Chen CT, Hsu TI, Chen BS, Wu SN.
- Toxicology. 2011 Feb 4;280(1-2):1-9. doi: 10.1016/j.tox.2010.10.010. Epub 2010 Nov 20.
- An empirical study on the selection of analytes and corresponding cutoffs for immunoassay and GC-MS in a two-step test strategy--buprenorphine example.
- Wu MY, Wang YS, Lin CC, Lin DL, Su LW, Huang MH, Liu RH.
- Analyst. 2009 Sep;134(9):1848-56. doi: 10.1039/b902137j. Epub 2009 Jul 3.
- Thymol-evoked Ca+ mobilization and ion currents in pituitary GH3 cells.
- Shen AY, Huang MH, Wang TS, Wu HM, Kang YF, Chen CL.
- Nat Prod Commun. 2009 Jun;4(6):749-52.
- A novel derivatization approach for simultaneous determination of glyoxal, methylglyoxal, and 3-deoxyglucosone in plasma by gas chromatography-mass spectrometry.
- Wu MY, Chen BG, Chang CD, Huang MH, Wu TG, Chang DM, Lee YJ, Wang HC, Lee CI, Chern CL, Liu RH.
- J Chromatogr A. 2008 Sep 12;1204(1):81-6. doi: 10.1016/j.chroma.2008.07.040. Epub 2008 Jul 19.
- Gas chromatography-mass spectrometry analysis of ketamine and its metabolites--a comparative study on the utilization of different derivatization groups.
- Wu CH, Huang MH, Wang SM, Lin CC, Liu RH. 2
- J Chromatogr A. 2007 Jul 20;1157(1-2):336-51. Epub 2007 Apr 21.
- Performance characteristics of ELISAs for monitoring ketamine exposure.
- Huang MH, Wu MY, Wu CH, Tsai JL, Lee HH, Liu RH.
- Clin Chim Acta. 2007 Apr;379(1-2):59-65. Epub 2006 Dec 22.
- Stimulatory actions of thymol, a natural product, on Ca(2+)-activated K(+) current in pituitary GH(3) cells.
- Huang MH, Wu SN, Shen AY.
- Planta Med. 2005 Dec;71(12):1093-8.
- Glucocorticoids stimulate the activity of large-conductance Ca2+ -activated K+ channels in pituitary GH3 and AtT-20 cells via a non-genomic mechanism.
- Huang MH, So EC, Liu YC, Wu SN.
- Steroids. 2006 Feb;71(2):129-40. Epub 2005 Nov 4.
- Antioxidant and antiplatelet effects of dang-gui-shao-yao-san on human blood cells.
- Shen AY, Wang TS, Huang MH, Liao CH, Chen SJ, Lin CC.
- Am J Chin Med. 2005;33(5):747-58.
- Effects of 4-piperidinomethyl-2-isopropyl-5-methylphenol on oxidative stress and calcium current.
- Huang MH, Liao LF, Kuo SH, Chen CL, Shen AY.
- J Pharm Pharmacol. 2005 Sep;57(9):1191-7.
- Characterization of chromanol 293B-induced block of the delayed-rectifier K+ current in heart-derived H9c2 cells.
- Lo YC, Yang SR, Huang MH, Liu YC, Wu SN.
- Life Sci. 2005 Apr 1;76(20):2275-86. Epub 2005 Jan 27.
- Sodium cyanate-induced opening of calcium-activated potassium currents in hippocampal neuron-derived H19-7 cells.
- Huang CW, Huang CC, Huang MH, Wu SN, Hsieh YJ.
- Neurosci Lett. 2005 Mar 29;377(2):110-4. Epub 2004 Dec 21.
- Stimulatory actions of caffeic acid phenethyl ester, a known inhibitor of NF-kappaB activation, on Ca2+-activated K+ current in pituitary GH3 cells.
- Lin MW, Yang SR, Huang MH, Wu SN.
- J Biol Chem. 2004 Jun 25;279(26):26885-92. Epub 2004 Mar 23.
- Cilostazol, an inhibitor of type 3 phosphodiesterase, stimulates large-conductance, calcium-activated potassium channels in pituitary GH3 cells and pheochromocytoma PC12 cells.
- Wu SN, Liu SI, Huang MH.
- Endocrinology. 2004 Mar;145(3):1175-84. Epub 2003 Nov 26.
研討會論文
- 2008 Annual Meeting of the Society of Forensic Toxicologists :Meng-Yan Wu, Yu-Shan Wang, Mei-Han Huang, Ray H. Liu, and Lien-Wen Su: Evaluation of Buprenorphine Immunoassays for Compliance Monitoring inHeroin Substitution Therapy Program
- 2008 ICCT（International Chemical Conference Taipei）: Chih-Yu Loa, Meng-Yan Wu,
- Ching-Chiang Lin, Sang-Jang Wang, Hung-Chi Wu, Mei-Han Huang*, Ray H. Liu*： Immunoassay and GC-MS Analysis of Methadone and Its Metabolites in Urine Specimens from Patients under Substitution Therapy
- 2009 Annual Meeting of the Society of Forensic Toxicologists: Mei-Han Huang,
- Chih-Yu Lo, Meng-Yan Wu, Ching-Chiang Lin, Sang-Jang Wang, Hung-Chi Wu, Ray
- H. Liu： Performance Characteristics of Methadone Immunoassays and Correlation of Analyte Concentrations as Cetermined by Immunoassays and GC-MS
- Inhibitory action of methadone and its metabolites on erg-mediated K+ current in GH3 pituitary tumor cells（研討會：98 年度台灣藥學會年會暨社區藥局實習教學國際研討會，起迄日：2009/11/28～2009/11/28）
- Performance Characteristics of Methadone Immunoassays and Correlation of Analyte Concentrations as Determined by Immunoassays and GC-MS（研討會：2009 S.O.F.T. annual meeting，起迄日：2009/10/19～2009/10/23）
- Effect of Methadone on Human Kidney Cel（l 研討會：2014 海峽兩岸檢驗醫學論壇，起迄日：2014/08/23～2014/08/24）
- 以GC/MS 評估Carbamazepine 與RAW細胞對Carbamazepine影響 (社團法人台灣醫事檢驗學會106 年度會員（代表）大會暨學術發表會)
研究計畫
- 96 年度—Buprenorphine 酵素免疫分析各套裝試劑特性及其檢測數據與GC-MS 間閾值的相關性 （DOH96-NNB-1006）
- 97 年度—Methadone 免疫分析套裝試劑之特性的探討及其檢測數據與C-MS 間閾值的相關性 （DOH97-NNB-1004）
- 99 年度—Ketamine 尿液檢驗標準方法之建立與閾值之相關探討(DOH99-FDA-71011)
- 100 年度—Ketamine 及其代謝物對於腦神經細胞與腎臟細胞效應之探討(NSC 100-2320-B-242 -001-)
- 101 年度—提昇濫用藥物尿液檢驗機構品質認可措施之探討(DOH101-FDA-11007)
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