羅宏仁｜Lo, Horng-Ren

🎓 師資介紹　

🎓　專任副教授

👨‍🎓　國立成功大學

　　基礎醫學所博士

📞　07-7811151 轉 7922

📧　mt096@fy.edu.tw

📖　學術專長

醫學分子檢驗、微生物抗藥機制、細菌致病機轉、生物化學

學歷

成功大學基礎醫學所博士(2010)
台灣大學生化學所碩士(1995)
台北醫學大學公共衛生學系學士(1992)

經歷

輔英科技大學醫學檢驗生物技術系助理教授(2011 / 08-2020 / 01)
輔英科技大學醫學檢驗生物技術系講師(1998 / 09 - 2011 / 07)
國科會研究助理(1997 / 09 - 1998 / 07)

學術專長

微生物致病機轉
醫學分子檢驗
生物化學
細菌抗藥機制

專題/論文指導

抗菌試劑對多重抗藥性細菌之協同作用
藥物幫浦基因在細菌抗藥機制所扮演角色
細胞外泌體於細菌誘導之敗血症的治療效果

證照

期刊論文

Chung-Cheng Lo, Tzu-Hui Yeh, Ya-Hsuan Jao, Tzu-Hui Wang, Horng-Ren Lo*. Efficacy of outer membrane permeabilization in promoting aromatic isothiocyanates-mediated eradication of multidrug resistant Gram-negative bacteria and bacterial persisters. Folia Microbiol (Praha). (2024) (SCI), MOST 111–2637-B-242–001, VHLC-11108, VHLC-11115
Shue-Ren Wann, Horng-Ren Lo, Yun-Te Chang, Jia-Bin Liao, Zhi-Hong Wen, Pei-Ling Chi. P2X7 receptor blockade reduces pyroptotic inflammation and promotes phagocytosis in Vibrio vulnificus infection. J Cell Physiol. (2023)
Tso-Ping Wang, Tzu-Hui Yeh, Chung-Cheng Lo, Kuan-Hua Lin, Mei-Han Huang, Horng-Ren Lo*. Synergistic action of indole-3-carbinol with membrane-active agents against multidrug-resistant Gram-negative bacteria. Lett Appl Microbiol. (2023). (SCI), MOST 110–2637-B-242–004, MOST 111–2637-B-242–001, KSVGH 110–022, KSVGH 111–045
Chung-Cheng Lo, Wan-Yu Liao, Miao-Chen Chou, Yu-Yi Wu, Tzu-Hui Yeh, Horng-Ren Lo*. Overexpression of RND efflux pump genes contributes to multidrug resistance in Aeromonas hydrophila clinical isolates. Microbial Drug Resistance (2022). (SCI), MOST 109-2637-B-242-002, VHLC-108007
Chung-Cheng Lo, Wan-Yu Liao, Miao-Chen Chou, Yu-Yi Wu, Tzu-Hui Yeh, Horng-Ren Lo*. Overexpression of RND efflux pump genes contributes to multidrug resistance in Aeromonas hydrophila clinical isolates. Microbial Drug Resistance (Accepted, 2021). (SCI), MOST 109-2637-B-242-002, VHLC-108007
Kuan-Hua Lin, Chung-Cheng Lo, Miao-Chen Chou, Tzu-Hui Yeh, Kai-lin Chen, Wan-Yu Liao, Horng-Ren Lo*. Synergistic Actions of Benzyl Isothiocyanate with EDTA and Efflux Pump Inhibitor Phenylalanine-arginine β- naphthylamide Against Multidrug Resistant Escherichia coli. Microbial Drug Resistance (2019) Nov 22. (SCI), VHLC-106012
Chia-Jung Kuo, Chun-Ya Chen , Horng-Ren Lo, Chun-Lung Feng, Hui-Yu Wu, Mei-Zi Huang, Tung-Nan Liao, Yu-An Chen and Chih-Ho Lai. Helicobacter pylori Induces IL-33 Production and Recruits ST-2 to Lipid Rafts to Exacerbate Inflammation. Cells (2019) 8; 10. (SCI)
Hwai-Jeng Lin, Zhi-Pei Jiang, Horng-Ren Lo, Chun-Lung Feng, Chih-Jung Chen, Chia-Yu Yang,Mei-Zi Huang,Hui-Yu Wu,Yu-An Chen,Yu Chen, Cheng-Hsun Chiu, and Chih-Ho Lai, Coalescence of RAGE in Lipid Rafts in Response to Cytolethal Distending Toxin-Induced Inflammation (2019) Front Immunol. 10: 109. (SCI)
Chung-Cheng Lo, Pei-Ting Lin, Chuan Chiang-Ni, Kuan-Hua Lin, Shin-Luen Lee, Tzu-Fang Kuo, Horng-Ren Lo*, “Contribution of efflux systems to the detergent resistance, cytotoxicity, and biofilm formation of Vibrio vulnificus” (2017) Gene Reports Volume 9, Pages 115-122 (AI-104032)
Wei-Chih Liao, Mei-ZiHuang, Michelle Lily Wang, Chun-JungLin, Tzu-Li Lu, Horng-Ren Lo, Yi-JiunPan, Yu-Chen Sun, Min-Chuan Kao, Hui-JingLim and Chih-Ho Lai “Statin Decreases Helicobacter pylori Burden in Macrophages by Promoting Autophagy” (2017) Front. Cell. Infect. Microbiol., 17
Soong-Yu Kuo, Miao-Chen Chou, Shin-Luen Lee, Yu Wang, Chun-Liang Chen, Pei-Ting Lin, Horng-Ren Lo*. Vibrio vulnificus RtxA1 modulated calcium flux contributes reduced internalization in phagocytes (2015). Life Sci. 1(132):55-60 (SCI)
Chung-Ren Jan, Horng-Ren Lo, Chung-Yi Chen, and Soong-Yu Kuo Effect of allyl sulfides from garlic essential oil on intracellular Ca2+ levels in renal tubular cells. (2012) J Nat Prod. 75(12):2101-7. (SCI)
Horng-Ren Lo, Jen-Hsing Lin, Yi-Hsuan Chen, Chun-Liang Chen,Chung-Ping Shao, Yi-Chi Lai, and Lien-I Hor. RTX toxin enhances the survival of Vibrio vulnificus during infection by protecting the organism from phagocytosis.(2011) J Infect Dis 203(12): 1866-74. (SCI)
Chung-Ping Shao,Horng-Ren Lo, Jen-Hsing Lin, and Lien-I Hor. "Regulation of cytotoxicity by quorum-sensing signaling in Vibrio vulnificus is mediated by SmcR, a repressor of hlyU. (2011) J Bacteriol 193(10): 2557-65. (SCI)

研討會論文

Huei-Cin Sie, Tso-Ping Wang, Yu-Chi Su, Tsai-Jie Lo, Meng-Zhen Tsai, Hong-Fu Huang, Yu-Yi Wu, Horng-Ren Lo, Pei-Xin Lu, Mei-Han Huang. Evaluation of the antibacterial effect of isothiocyanate combined with antibiotics on multidrug-resistant strains of Pseudomonas aeruginosa. 2021 第12 屆亞太醫學檢驗科學國際研討會
Tzu-Hui Yeh, Yu-Ching Chen, Jia-Ying Chien, Yi-An Chen, Yu-Yi Wu, Pei-Xin Lu, Ling-Huei Luo, Horng-Ren Lo, Miao-Chen Chou. Bactericidal effect of combined use of antibacterial peptides and efflux pump inhibitor against multidrug resistant Pseudomonas aeruginosa. 2021 第12 屆亞太醫學檢驗科學國際研討會
Chun-Ya Chen, Sue-Ling Chou, Hong-Fu Huang, Wen-Yan Huang, Yi-Ting Hsieh, Yu-Yi Wu, Horng-Ren Lo. Effects of nanoparticles in inhibiting multidrug resistant bacteria and biofilm. 2021 第12 屆亞太醫學檢驗科學國際研討會
Chung-Cheng Lo, Tsai-Jie Lo, Min-Chiun Tsai, Horng-Ren Lo, Miao-Chen Chou, Guan-Hua Lin, Ying-Hsuan Chen. Protective effects of Inonotus sp. crude polysaccharide extract on Pseudomonas aeruginosa PAO1 infection of Caenorhabditis elegans. 2020海峽兩岸檢驗醫學論壇暨第20屆海峽兩岸檢驗醫學學術交流會議 (Cross-strait Laboratory Medicine Symposium in 2020)
Tzu-Hui Yeh, Chung-Cheng Lo, Yu-Yi Wu, Kuan-Hua Lin, Miao-Chen Chou, Horng-Ren Lo. Synergistic activity of isothiocyanates and adjuvant agents against multidrug- resistant Gram negative bacteria. 2019細菌學研討會
Horng-Ren Lo, Shu-Jhen Chiu, Jhu-Jyun Ke, Wei-Chang Tseng, Chung-Cheng Lo Modulatory effect of Vibrio vulnificus RtxA1 cytotoxin on oxidative stress in blood. 2018醫檢學會
Ching-Hui Wang, Ching-Chiang Lin, Wan-Yu Liao, Shin-Luen Lee, Kuan-Hua Lin, Horng-Ren Lo. RND-Type Efflux Pumps in Multidrug-Resistant Clinical Isolates of Aeromonas 2017 International Congress of Chemotherapy and Infection (ICC)
Tzu-Hui Yeh, Chung-Cheng Lo, Kai-lin Chen, Kuan-Hua Lin , Miao-Chen Chou, Horng-Ren Lo Application of isothiocyanates as effective agents against multidrug- resistant Escherichia coli 2017 International Congress of Chemotherapy and Infection (ICC)
Chung-Cheng Lo, Ying-Hsuan Chen, Kai-Wei Zeng, Kuan-Hua Lin, Mei-Han Huang, Horng-Ren Lo. Crude polysaccharide from Inonotus sp. protects Caenorhabditis elegans against Pseudomonas aeruginosa PAO1 infection. 2017細菌學研討會
Zhi-Pei Jiang , Chi-Liang Chern, Horng-Ren Lo. The effectiveness of Phellinus polysaccharide stimulated mouse phagocytes in bacteria killing 2015細菌學研討會
Yong-An Shi, Tzu-Hui Yeh, Mei-Ying Wang, Soong-Yu Kuo, Horng-Ren Lo. The application of benzyl isothiocyanate to control the growth of multiple drug resistance Escherichia coli 2015細菌學研討會
Chung-Cheng Lo, Shin-luen Lee, Pei-Ting Lin, Horng-Ren Lo. The modulation of Vibrio vulnificus RtxA1 on murine macrophage-like RAW264.7 cells 2015細菌學研討會
Gin-Chi Lin, Pei-Ting Lin, Shin-luen Lee, Horng-Ren Lo. The Biological Role of Vibrio vulnificus AcrB homologs in stress resistance 2015細菌學研討會
Chun-Ya Chen, Zhi-Pei Jiang, Yong-An Shi, Horng-Ren Lo. Characterization of Vibrio vulnificus ompU mutant in stress resistance 2015細菌學研討會
Hsiao Kuang-Hung, Yu Wang, Mei-Zi Huang, Shin-Luen Lee, Horng-Ren Lo The aberrant cellular calcium response induced by Vibrio vulnificus RTX toxin. 2013細菌學研討會
Mei-Zi Huang, Soong-Yu Kuo, Yu Wang, Horng-Ren Lo The effects of intracellular calcium induced by Vibrio vulnificus RTX toxin. 2012細菌學研討會

研究計畫

人類誘導型幹細胞衍生外泌小體對於創傷弧菌致病之影響主持人 2021/1/1~2021/12/30
陽離子抗菌肽對多重抗藥性鮑氏不動桿菌(Acinetobacter baumannii)生物膜形成和運動性之研究主持人 2021/1/1~2021/12/30
金屬整合劑對抗藥性綠膿桿菌的抑菌活性分析主持人 2021/1/1~2021/12/30
iPSC衍生的外泌體對創傷孤菌細胞毒素介導NACHT, LRR and PYD domains-containing protein 3 (NLRP3)依賴性發炎體(inflammasome) 活化之調理作用主持人 2021/1/1~2021/12/30
金屬螯合劑對抗持留性細菌之應用(2/2) 主持人 2020/8/1~2022/7/31
探討誘導型多功能幹細胞之外泌小體對於創傷弧菌感染所扮演之角色主持人 2020/1/1~2020/12/30
纖孔菌屬真菌多醣免疫調控機制之探討主持人 2020/1/1~2020/12/30
探討幹細胞胞泌小體應用於海洋弧菌引起之敗血症的治療主持人 2019/1/1~2019/12/30
真菌多醣對秀麗隱桿線蟲於細菌感染之保護效果主持人 2019/1/1~2019/12/30
探討創傷弧菌RTX細胞毒素在血液中所誘發的氧化壓力主持人 2018/1/1~2018/12/30
開發以輔助分子合併抗菌天然藥物對抗多重抗藥革蘭氏陰性細菌之心策略主持人 2018/7/1~2019/2/28
探討創傷弧菌RTX細胞毒素在血液中所誘發的氧化壓力指導老師 2018/7/1~2019/2/28
產氧單胞菌藥物轉運蛋白質與多重抗藥性的相關探討共同(協同)主持人 2016/8/1~2018/7/31
RND外排幫浦在產氣單胞菌多重抗藥性所扮演的角色主持人 2017/1/1~2017/12/30
建立Ce-Duox1/BLI-3基因(表現)減量之秀麗隱桿線蟲作為伺機性細菌感染之平台主持人 2017/1/1~2017/12/30
異硫氰酸酯對臨床抗藥菌株殺菌作用之評估 2016/01 ~ 2016/12
AcrB在抗藥活性之探討2015/01 ~ 2015/12
RtxA1毒素對吞噬細胞的免疫調控機制 2015/01 ~ 2015/12
創傷弧菌外膜蛋白質(ompU)因應膽鹽所產生的逆境反應 2014/01 ~ 2014/12
細菌莢膜多醣體對創傷弧菌菌落化能力之影響共同主持人2014/01 ~ 2014/12
創傷弧菌抗逆境因子在細菌致病過程所扮演角色 (101-2320-B-242 -001) /主持人/2012/08/01~2013/07/31/國科會

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