王怡棻｜Wang, Yi-Fen

🎓 師資介紹　

🎓　專任副教授

👨‍🎓　英國里茲大學

　　微生物學博士

📞　07-7811151 轉 5415

📧　sc071@fy.edu.tw

📖　學術專長

腫瘤病毒學、分子病毒學、微生物學、細胞分子生物學

學歷

英國里茲大學微生物學博士(1994)
國立台灣大學醫學院生化學研究所碩士(1988)
國立陽明大學醫事技術系學士(1985)

經歷

輔英科技大學/醫技系/助理教授
中央研究院/生物醫學研究所/癌症研究組/博士後研究員
輔英醫事護理專科學校/醫技科/講師
台北榮民總醫院/醫研部/研究助理

學術專長

人類庖疹病毒第八型病毒致病與致癌機轉之探討
腫瘤病毒學
分子病毒學
分子生物學
細胞生物學
微生物

專題/論文指導

109學年度碩士論文指導
阿斯匹靈誘導原發性積液淋巴瘤細胞死亡及人類疱疹病毒第八型再活化-林潔如
人類疱疹病毒第八型vBcl-2調控內質網壓力相關蛋白和類鐸受體第4型以維持細胞的恆定-黃子凌
109學年度專題
HSF1對Ferroptosis、m6A修飾及 HHV8複製影響之研究-葉于瑄
內質網壓力和鐵依賴型細胞死亡調控人類疱疹病毒第八型複製之研究-梁珈瑀
108學年度碩士論文指導
探討熱休克因子1在調控人類疱疹病毒第八型病毒複製之角色-吳冠璋
EGCG調控原發性積液淋巴瘤細胞代謝路徑之研究-葉玲君
107學年度專題
阿斯匹靈誘導原發性滲出性淋巴瘤細胞死亡機制之研究-林潔如
內質網壓力對人類疱疹病毒第八型vBcl-2調控病毒複製之影響-黃子凌
106學年度專題
多酚類調控原發性積液淋巴瘤細胞代謝路徑之研究-葉玲君
人類疱疹病毒第八型 vBcl-2 增加病毒複製並誘導內質網壓力-柯品如、
105學年度專題
多酚類誘導原發性浸潤淋巴瘤細胞衰老與代謝干擾-李憶萱
醣化終產物誘導原發性浸潤淋巴瘤中人類疱疹病毒第八型病毒再活化-蔡蔚綺
104學年度專題
細胞蛋白熱休克因子調控人類疱疹病毒第八型病毒之再活化-彭孝慈
人類疱疹病毒第八型vBcl-2誘導對內質網壓力相關基因之表現-楊中銓
103學年度專題
細胞蛋白熱休克因子1可調控人類疱疹病毒第八型病毒之感染-陳冠錡
多酚類藥物對人類疱疹病毒第八型之影響-陳誼欣

證照

中華民國醫事檢驗師

期刊論文

Ling-Chun Yeh, Huey-Wen Shyu, Yi-Ru Jin, Yee-Hsuan Chiou, Kuan-Hua Lin,
Miao-Chen Chou, Mei-Han Huang, Yi-Fen Wang*, 2020, Epigallocatechin-3-gallate
downregulates PDHA1 interfering the metabolic pathways in human herpesvirus 8
harboring primary effusion lymphoma cells, Toxicology in Vitro, 65, 104753
Yi-Fen Wang, Ming-Huang Wang & Yuh-Shan Ho, 2020, A bibliometric analysis of
KSHV/HHV8 research, COLLNET Journal of Scientometrics and Information Management, 14, 219-235 (ESCI)
Ching-Yi Tsai , Chang-Yu Chen, Yee-Hsuan Chiou, Huey-Wen Shyu, Kuan-Hua Lin,Miao-Chen Chou, Mei-Han Huang, Yi-Fen Wang*, 2018, Epigallocatechin-3-Gallate Suppresses Human Herpesvirus 8 Replication and Induces ROS Leading to Apoptosis and Autophagy in Primary Effusion Lymphoma Cells, International Journal of Molecular Sciences, 19, 16 (SCI
Feng-Yi Tang, Chang-Yu Chen, Huey-Wen Shyu, Shin Hong, Hung-Ming Chen, Yee-Hsuan Chiou, Kuan-Hua Lin, Miao-Chen Chou, Lin-Yu Wang, Yi-Fen Wang (?), 2015, Resveratrol induces cell death and inhibits human herpesvirus 8 replication in primary effusion lymphoma cells. Chemico-Biological Interactions, 242:372-379. (SCI).
Yi-Fen Wang * , Yee-Hsuan Chiou, Lin-YuWang, Su-Ting Chang, Huey-Wen Shyu, Chang-Yu Chen, Kuan-Hua Lin, and Miao-Chen Chou, 2012, Cisplatin Disrupts the Latency of Human Herpesvirus 8 and Induces Apoptosis in Primary Effusion Lymphoma Cells. Cancer Investigation, 30(4):268-74. (SCI).
Yi-Fen Wang, Huey-Wen Shyu, Yi-Chuang Chang, Wei-Chang Tseng, Yeou-Lih Huang, Kuan-Hua Lin, Miao-Chen Chou, Heng-Ling Liu, Chang-Yu Chen, 2012, Nickel (II)-induced cytotoxicity and apoptosis in human proximal tubule cells through a ROS- and mitochondria-mediated pathway. Toxicology and Applied Pharmacology, 259, 177–186. (SCI).
Shyu HW, Lin YY, Chen LC, Wang YF, Yeh TM, Su SJ, Cheng WC, Chen CY,Lin KH, Chou MC, 2010, The dengue virus envelope protein induced PAI-1 gene expression via MEK/ERK pathways. Thromb Haemost, 104(6):1219-27. (SCI).
Wang YF (?), Wang LY, Li YL, Shyu HW, Chiou YH, Chou MC, Lin KH, Tai MH, Chen CY, 2010, Human herpesvirus 8 viral FLICE-inhibitory protein retards cell proliferation via downregulation of Id2 and Id3 expression.. Mol Cell Biochem, 343:83–89. (SCI).
Chen LC, Yeh TM, Lin YY, Wang YF, Su SJ, Chen CY, Lin KH, Chou MC, Shyu HW, 2010, The envelope glycoprotein domain III of Dengue virus type 2 induced the expression of anticoagulant molecules in endothelial cells.. Mol Cell Biochem, 342:215–221. (SCI).
Chen CY, Lin TK, Chang YC, Wang YF, Shyu HW, Lin KH, Chou MC, 2010, Nickel(II)-induced oxidative stress, apoptosis, G2/M arrest, and genotoxicity in normal rat kidney cells.. Journal of Toxicology and Environmental Health, 73: 339-349. (SCI).

研討會論文

G.Z. Wu, H.W Shyu, K.H. Lin, M.C. Chou, M.H. Huang, Y.-F. Wang* (2019) Heat Shock Factor 1 Modulates Human Herpesvirus 8 Replication. Abstr.CM054 , The 34th Joint Annual Conference of Biomedical Science. Taipei.
L.C. Yeh, H.W. Shyu, M.C. Chou, M.H. Huang, K.H. Lin, Y.-F. Wang* (2019) Epigallocatechin-3-gallate Modulates the Metabolic Pathway of Primay Effusion Lymphoma Cells. Abstr.CM011 , The 34th Joint Annual Conference of Biomedical Science. Taipei.
J.L. Liu, P.J. Ko, H.W. Shyu, M. C. Chou, K.H. Lin, M.H. Huang, Y.-F. Wang* (2018) Human Herpesvirus 8 viral Bcl-2 Increases Viral Replication and Induces Endoplasmic Reticulum Stress. Abstr. D2, Cross-strait Laboratory Medicine Symposium in 2018
J.L. Liu, S.C. Huang, L.C. Yeh, Y. S. Lee, H.W. Shyu, M. C. Chou, Y.-F. Wang* (2017) Epigallocatechin-3-gallate Induces Cell Senescence and Metabolic Reprogramming in Human Herpesvirus 8 Harboring Primary Effusion Lymphoma Cells. Abstr. C20, Cross-strait Laboratory Medicine Symposium in 2017
Y.S. Lee, F.Y. Tang, C.Y Chen, H.W Shyu, W.C. Tsai, M.C. Chou, M.H. Huang & Y.-F. Wang* (2017) Resveratrol Induces Cell Senescence and Metabolic Perturbation in Primary Effusion lymphoma cells. Abstr. CM133, The 32th Joint Annual Conference of Biomedical Science. Taipei.
W.C. Tsai, M.S. Kuo, M.C. Chou, K.H. Lin, C.Y. Chen, H.W. Shyu, Y.S Lee & Y.-F. Wang* (2017) Advanced Glycation End Products Induce Human Herpevirus 8 Reactivation in Primary effusion lymphoma cells. Abstr. CM095, The 32th Joint Annual Conference of Biomedical Science. Taipei.
S.C. Peng, C.Y. Chen, H.W. Shyu, K.H Lin, M.C. Chou & Y.-F. Wang* (2016) Heat Shock Factor 1 Regulates Human Herpesvirus 8 Reactivation. Abstr. P401, The 31th Joint Annual Conference of Biomedical Science. Taipei.
Y.S. Chen, C.Y. Chen, H.W. Shyu, F.Y. Tang, L.Y. Wang, K.H. Lin, M.C. Chou & Y.F. Wang* The Effects of Polyphenols on Human Herpesvirus 8 Replication, (2015) The 30th Joint Annual Conference of Biomedical Science.
K.C. Chen, C.Y. Chen, H.W. Shyu, L.Y. Wang, K.H. Lin, M.C. Chou & Y.F. Wang* Heat shock factor 1 is critical for human herpesvirus 8 infection, (2015) The 30th Joint Annual Conference of Biomedical Science.
S. Hong, F.Y. Tang, H.W. Shyu, C.Y. Chen, C.Y. Tsai, L.Y. Wang, M.C. Chou & Y.F. Wang* Resveratrol Induces Apoptosis and Autophagy in HHV8 Harboring Primary Effusion Lymphoma Cells (2013) The 28th Joint Annual Conference of Biomedical Science.
C.Y. Tsai, C.Y. Chen, H.W. Shyu, K.H. Lin, M.C. Chou & Y.F. Wang* Epigallocatechin-3-gallate Induces Cell Death and Reduces HHV8 Viral Replication in Primary Effusion Lymphoma Cells. (2013) The 28th Joint Annual Conference of Biomedical Science..
Y.F. Wang*, C.Y. Tsai, C.Y. Chen, H.W. Shyu & M.C. Chou Epigallocatechin-3-gallate Induces Cell Death in Primary Effusion Lymphoma Cells. (2013), Cold Spring Harbor Asian Conference: Mechanisms and functions of non-apoptotic cell death.
Z.Y. Weng, F.Y. Tang, Y.F. Wang & H.W. Shyu. Lei-Gong Teng induces autophagy in non-small cell lung carcinoma cells. (2013), Cold Spring Harbor Asian Conference: Mechanisms and functions of non-apoptotic cell death.

研究計畫

Effects of aspirin on human herpesvirus 8 harboring primary effusion lymphoma cells. 2019 高雄榮民總醫院 (共同主持人)
Role of Heat Shock factor 1 on human herpesvirus 8 Infection and virus induced metabolic perturbation. (MOST 106-2320-B-242-001) 2017科技部(主持人)
Effects of human herpesvirus 8 vBcl-2 on endoplasmic reticulum stress and heme oxygenase-1. 2018 高雄市立聯合醫院(共同主持人)
Study on EGCG induced cell senescence and metabolic perturbation in primary effusion lymphoma cells. 2017 高雄市立聯合醫院(共同主持人)
Study on Resveratrol induced cell senescence and metabolic perturbation in primary effusion lymphoma cells. 2016 (RG16014) 阮綜合醫院 (共同主持人)
Effects of resveratrol on the human herpesvirus 8 microRNA expression in primary effusion lymphoma cell. (RG15-012) 2015阮綜合醫院(共同主持人)
The effects of advanced glycation end products on human herpevirus 8 replication,, 2015 天主教聖功醫療財團法人聖功醫院 (共同主持人)
Study on Resveratrol induced cell death in the human herpesvirus 8 harboring PEL cells. (RG13-005) 2013阮綜合醫院 (共同主持人)
The effects of human herpesvirus 8 encoded vFLIP on ER stress and autophagy. (NSC 100-2320-B-242 -002) 2011 科技部(主持人)
The effects of human herpesvirus 8 encoded vFLIP on cells and the cellular genes (NSC 97-2320-B-242 -003 -MY3) 2008-2011 科技部(主持人)

榮譽事蹟

109學年度學生醫技研究方法成果競賽第二名 (葉于瑄) 指導老師佳作(梁珈瑀)
109學年度輔英科技大學績優導師
108學年度輔英科技大學績優導師
107學年度輔英科技大學績優導師
107學年度輔英科技大學績優導師
107學年度第一學期輔英科技大學教學評量績優課程 (微生物學)
107學年度學生醫技研究方法成果競賽第三名 (黃子凌) 指導老師佳作(林潔如)
106學年度學生醫技研究方法成果競賽第二名 (葉玲君) 指導老師

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