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王怡棻｜Wang, Yi-Fen　

王怡棻｜Wang, Yi-Fen
王怡棻｜Wang, Yi-Fen
🎓　專任副教授
👨‍🎓　英國里茲大學
　　 微生物學博士
📞　07-7811151 轉 5415
📧　sc071@fy.edu.tw
📖　學術專長
腫瘤病毒學、分子病毒學、微生物學、細胞分子生物學
學歷
  • 英國里茲大學微生物學博士(1994)
  • 國立台灣大學醫學院生化學研究所碩士(1988)
  • 國立陽明大學醫事技術系學士(1985)
經歷
  • 輔英科技大學/醫技系/助理教授
  • 中央研究院/生物醫學研究所/癌症研究組/博士後研究員
  • 輔英醫事護理專科學校/醫技科/講師
  • 台北榮民總醫院/醫研部/研究助理
學術專長
  • 人類庖疹病毒第八型病毒致病與致癌機轉之探討
  • 腫瘤病毒學
  • 分子病毒學
  • 分子生物學
  • 細胞生物學
  • 微生物
專題/論文指導
  • 113學年度專題指導
    探討鐵依賴性死亡在人類疱疹病毒第八型複製中之角色-林芳羽
  • 112學年度碩士論文共同指導
    Aspirin誘導原發性積液淋巴瘤細胞鐵依賴性死亡及調控m6A RNA修飾-蔡品儀
  • 112學年度專題指導
    Epigallocatechin gallate可增強阿斯匹靈對原發性滲出性淋巴瘤之細胞毒性並減緩阿斯匹靈所誘導HHV-8再活化-施佳妤
    人類疱疹病毒第八型 vBcl-2蛋白可減少 Ferroptosis誘導劑所引發之細胞死亡-黃宜瑄
  • 南部某區域醫院B群鏈球菌分離株抗藥性基因之分析-陳和鳳
  • 111學年度專題指導
    人類疱疹病毒第八型vBcl-2可減緩初級浸潤淋巴細胞發炎小體之活化-胡嘉真
    熱休克因子1調控人類疱疹病毒第八型再活化和m6A RNA修飾-蘇明樂
  • 110學年度專題指導
    阿斯匹靈誘導原發性滲出性淋巴瘤鐵依賴型細胞死亡及調控m6A RNA修飾之研究-蔡品儀
    熱休克因子1影響m6A RNA修飾和人類疱疹病毒第八型複製-林致平
  • 南部某區域醫院不溶血不產色之B群鏈球菌分離株之血清型分布及分子特性-郭哲宇
  • 109學年度碩士論文指導
    阿斯匹靈誘導原發性積液淋巴瘤細胞死亡及人類疱疹病毒第八型再活化-林潔如
    人類疱疹病毒第八型vBcl-2調控內質網壓力相關蛋白和類鐸受體第4型以維持細胞的恆定-黃子凌
  • 109學年度專題
    HSF1對Ferroptosis、m6A修飾及 HHV8複製影響之研究-葉于瑄
    內質網壓力和鐵依賴型細胞死亡調控人類疱疹病毒第八型複製之研究-梁珈瑀
  • 108學年度碩士論文指導
    探討熱休克因子1在調控人類疱疹病毒第八型病毒複製之角色-吳冠璋
    EGCG調控原發性積液淋巴瘤細胞代謝路徑之研究-葉玲君
  • 107學年度專題
    阿斯匹靈誘導原發性滲出性淋巴瘤細胞死亡機制之研究-林潔如
    內質網壓力對人類疱疹病毒第八型vBcl-2調控病毒複製之影響-黃子凌
  • 106學年度專題
    多酚類調控原發性積液淋巴瘤細胞代謝路徑之研究-葉玲君
    人類疱疹病毒第八型 vBcl-2 增加病毒複製並誘導內質網壓力-柯品如、
  • 105學年度專題
    多酚類誘導原發性浸潤淋巴瘤細胞衰老與代謝干擾-李憶萱
    醣化終產物誘導原發性浸潤淋巴瘤中人類疱疹病毒第八型病毒再活化-蔡蔚綺
  • 104學年度專題
    細胞蛋白熱休克因子調控人類疱疹病毒第八型病毒之再活化-彭孝慈
    人類疱疹病毒第八型vBcl-2誘導對內質網壓力相關基因之表現-楊中銓
  • 103學年度專題
  • 細胞蛋白熱休克因子1可調控人類疱疹病毒第八型病毒之感染-陳冠錡
    多酚類藥物對人類疱疹病毒第八型之影響-陳誼欣
證照
  • 中華民國醫事檢驗師
期刊論文

  • Hui-Fang Cheng, Zhe-Yu Kuo, Ching-Chiang Lin, Ho-Feng Chen, Horng-Ren Lo, · Huey-Wen Shyu, Yi-Fen Wang*, 2025, Analysis of serotype distribution and characteristics of nonhemolytic and nonpigmented strains among group B Streptococcus isolates in a southern Taiwan local hospital, Eur J Clin Microbiol Infect Dis 44(2):303-310. doi: 10.1007/s10096-024-05000-9

  • Ling-Chun Yeh, Huey-Wen Shyu, Yi-Ru Jin, Yee-Hsuan Chiou, Kuan-Hua Lin,Miao-Chen Chou, Mei-Han Huang, Yi-Fen Wang*, 2020, Epigallocatechin-3-gallate downregulates PDHA1 interfering the metabolic pathways in human herpesvirus 8 harboring primary effusion lymphoma cells, Toxicology in Vitro, 65, 104753
  • Yi-Fen Wang, Ming-Huang Wang & Yuh-Shan Ho, 2020, A bibliometric analysis of KSHV/HHV8 research, COLLNET Journal of Scientometrics and Information Management, 14, 219-235 (ESCI)
  • Ching-Yi Tsai , Chang-Yu Chen, Yee-Hsuan Chiou, Huey-Wen Shyu, Kuan-Hua Lin,Miao-Chen Chou, Mei-Han Huang, Yi-Fen Wang*, 2018, Epigallocatechin-3-Gallate Suppresses Human Herpesvirus 8 Replication and Induces ROS Leading to Apoptosis and Autophagy in Primary Effusion Lymphoma Cells, International Journal of Molecular Sciences, 19, 16 (SCI
  • Feng-Yi Tang, Chang-Yu Chen, Huey-Wen Shyu, Shin Hong, Hung-Ming Chen, Yee-Hsuan Chiou, Kuan-Hua Lin, Miao-Chen Chou, Lin-Yu Wang, Yi-Fen Wang *, 2015, Resveratrol induces cell death and inhibits human herpesvirus 8 replication in primary effusion lymphoma cells. Chemico-Biological Interactions, 242:372-379. (SCI).
  • Yi-Fen Wang * , Yee-Hsuan Chiou, Lin-YuWang, Su-Ting Chang, Huey-Wen Shyu, Chang-Yu Chen, Kuan-Hua Lin, and Miao-Chen Chou, 2012, Cisplatin Disrupts the Latency of Human Herpesvirus 8 and Induces Apoptosis in Primary Effusion Lymphoma Cells. Cancer Investigation, 30(4):268-74. (SCI).
  • Yi-Fen Wang, Huey-Wen Shyu, Yi-Chuang Chang, Wei-Chang Tseng, Yeou-Lih Huang, Kuan-Hua Lin, Miao-Chen Chou, Heng-Ling Liu, Chang-Yu Chen, 2012, Nickel (II)-induced cytotoxicity and apoptosis in human proximal tubule cells through a ROS- and mitochondria-mediated pathway. Toxicology and Applied Pharmacology, 259, 177–186. (SCI).
  • Shyu HW, Lin YY, Chen LC, Wang YF, Yeh TM, Su SJ, Cheng WC, Chen CY,Lin KH, Chou MC, 2010, The dengue virus envelope protein induced PAI-1 gene expression via MEK/ERK pathways. Thromb Haemost, 104(6):1219-27. (SCI).
  • Wang YF (?), Wang LY, Li YL, Shyu HW, Chiou YH, Chou MC, Lin KH, Tai MH, Chen CY, 2010, Human herpesvirus 8 viral FLICE-inhibitory protein retards cell proliferation via downregulation of Id2 and Id3 expression.. Mol Cell Biochem, 343:83–89. (SCI).
  • Chen LC, Yeh TM, Lin YY, Wang YF, Su SJ, Chen CY, Lin KH, Chou MC, Shyu HW, 2010, The envelope glycoprotein domain III of Dengue virus type 2 induced the expression of anticoagulant molecules in endothelial cells.. Mol Cell Biochem, 342:215–221. (SCI).
  • Chen CY, Lin TK, Chang YC, Wang YF, Shyu HW, Lin KH, Chou MC, 2010, Nickel(II)-induced oxidative stress, apoptosis, G2/M arrest, and genotoxicity in normal rat kidney cells.. Journal of Toxicology and Environmental Health, 73: 339-349. (SCI).
研討會論文
  • Jung-Lin Liu, Pin-Yi Tsai, Fang-Yu Lin, Yi-Fen Wang* (2025) Epigallocatechin gallate attenuates aspirin-induced HHV-8 lytic replication. Abstr., The 8th AAMLS  congress/The 16th APFML
  • Jung-Lin Liu, Pin-Yi Tsai, Fang-Yu Lin, Huey-Wen Shyu, Yi-Fen Wang* (2024) Human Herpesvirus 8 viral Bcl-2 attenuates erastin-induced ferroptosis in primary effusion lymphoma cells. Abstr., The 15th APFMLS
  • Pin-Yi Tsai, Ming-Hong Tai, Huey-Wen Shyu & Yi-Fen Wang* (2024) Aspirin induces ferroptosis in primary effusion lymphoma cells. Abstr. , The 38th Joint Annual Conference of Biomedical Science. Taipei.
  • Jung-Lin Liu, Jia-Zhen Hu, Huey-Wen Shyu, Yi-Fen Wang* (2023) Human Herpesvirus 8 viral Bcl-2 attenuates inflammasome activation in primary effusion lymphoma cells. Abstr., The 14th APFMLS
  • Pin-Yi Tsai, Ming-Hong Tai, Yi-Ru Jin, Huey-Wen Shyu & Yi-Fen Wang* (2023) Aspirin modulates N6‐methyladenosine RNA modification in primary effusion lymphoma cells. Abstr. , The 37th Joint Annual Conference of Biomedical Science. Taipei.
  • Hui-Fang Cheng, Zhe-Yu Kuo, Ching-Chiang Lin, Huey-Wen Shyu, & Yi-Fen Wang* (2022) Serotype distribution and molecular characterization of nonhemolytic and nonpigmented group B Streptococcus isolates in a southern Taiwan local hospital. Abstr., The 13th APFMLS.
  • Yi-Ru Jin, Jie-Ru Lin, Yang-Ming Tseng, Pin-Yi Tsai, Huey-Wen Shyu, Kuan-Hua Lin & Yi-Fen Wang* (2021) Aspirin Induces ROS and Cell Cycle Arrest Leading to Cell Death in Primary Effusion Lymphoma Cells. Abstr., Cross-strait Laboratory Medicine Symposium in 2021 
  • Jung-Lin Liu, Zi-Ling Huang, Huey-Wen Shyu, Miao-Chen Chou, Mei-Han Huang, Yi-Fen Wang* (2021) vBcl-2 modulates ER stress related proteins to maintain cellular homeostasis for human herpesvirus 8 replication. Abstr., Cross-strait Laboratory Medicine Symposium in 2021 
  • Jie-Ru Lin, Yi-Ru Jin, Huey-Wen Shyu, Kuan-Hua Lin, Miao-Chen Chou, Mei-Han Huang, Yi-Fen Wang* (2020) Aspirin Induces ROS and Cell Cycle Arrest Leading to Cell Death in Primary Effusion Lymphoma Cells. Abstr., The 35th Joint Annual Conference of Biomedical Science. Taipei.
  • Zi-Ling Huang, Jung-Lin Liu, Huey-Wen Shyu, Miao-Chen Chou, Mei-Han Huang,Kuan-Hua Lin, Yi-Fen Wang* (2020) Human Herpesvirus 8 Viral Bcl-2 Modulates Viral Replication via Endoplasmic Reticulum Stress. Abstr., The 35th Joint Annual Conference of Biomedical Science. Taipei.
  • G.Z. Wu, H.W Shyu, K.H. Lin, M.C. Chou, M.H. Huang, Y.-F. Wang* (2019) Heat Shock Factor 1 Modulates Human Herpesvirus 8 Replication. Abstr.CM054 , The 34th Joint Annual Conference of Biomedical Science. Taipei.
  • L.C. Yeh, H.W. Shyu, M.C. Chou, M.H. Huang, K.H. Lin, Y.-F. Wang* (2019) Epigallocatechin-3-gallate Modulates the Metabolic Pathway of Primay Effusion Lymphoma Cells. Abstr.CM011 , The 34th Joint Annual Conference of Biomedical Science. Taipei.
  • J.L. Liu, P.J. Ko, H.W. Shyu, M. C. Chou, K.H. Lin, M.H. Huang, Y.-F. Wang* (2018) Human Herpesvirus 8 viral Bcl-2 Increases Viral Replication and Induces Endoplasmic Reticulum Stress. Abstr. D2, Cross-strait Laboratory Medicine Symposium in 2018
  • J.L. Liu, S.C. Huang, L.C. Yeh, Y. S. Lee, H.W. Shyu, M. C. Chou, Y.-F. Wang* (2017) Epigallocatechin-3-gallate Induces Cell Senescence and Metabolic Reprogramming in Human Herpesvirus 8 Harboring Primary Effusion Lymphoma Cells. Abstr. C20, Cross-strait Laboratory Medicine Symposium in 2017
  • Y.S. Lee, F.Y. Tang, C.Y Chen, H.W Shyu, W.C. Tsai, M.C. Chou, M.H. Huang & Y.-F. Wang* (2017) Resveratrol Induces Cell Senescence and Metabolic Perturbation in Primary Effusion lymphoma cells. Abstr. CM133, The 32th Joint Annual Conference of Biomedical Science. Taipei.
  • W.C. Tsai, M.S. Kuo, M.C. Chou, K.H. Lin, C.Y. Chen, H.W. Shyu, Y.S Lee & Y.-F. Wang* (2017) Advanced Glycation End Products Induce Human Herpevirus 8 Reactivation in Primary effusion lymphoma cells. Abstr. CM095, The 32th Joint Annual Conference of Biomedical Science. Taipei.
  • S.C. Peng, C.Y. Chen, H.W. Shyu, K.H Lin, M.C. Chou & Y.-F. Wang* (2016) Heat Shock Factor 1 Regulates Human Herpesvirus 8 Reactivation. Abstr. P401, The 31th Joint Annual Conference of Biomedical Science. Taipei.
  • Y.S. Chen, C.Y. Chen, H.W. Shyu, F.Y. Tang, L.Y. Wang, K.H. Lin, M.C. Chou & Y.F. Wang* The Effects of Polyphenols on Human Herpesvirus 8 Replication, (2015) The 30th Joint Annual Conference of Biomedical Science.
  • K.C. Chen, C.Y. Chen, H.W. Shyu, L.Y. Wang, K.H. Lin, M.C. Chou & Y.F. Wang* Heat shock factor 1 is critical for human herpesvirus 8 infection, (2015) The 30th Joint Annual Conference of Biomedical Science.
  • S. Hong, F.Y. Tang, H.W. Shyu, C.Y. Chen, C.Y. Tsai, L.Y. Wang, M.C. Chou & Y.F. Wang* Resveratrol Induces Apoptosis and Autophagy in HHV8 Harboring Primary Effusion Lymphoma Cells (2013) The 28th Joint Annual Conference of Biomedical Science.
  • C.Y. Tsai, C.Y. Chen, H.W. Shyu, K.H. Lin, M.C. Chou & Y.F. Wang* Epigallocatechin-3-gallate Induces Cell Death and Reduces HHV8 Viral Replication in Primary Effusion Lymphoma Cells. (2013) The 28th Joint Annual Conference of Biomedical Science..
  • Y.F. Wang*, C.Y. Tsai, C.Y. Chen, H.W. Shyu & M.C. Chou Epigallocatechin-3-gallate Induces Cell Death in Primary Effusion Lymphoma Cells. (2013), Cold Spring Harbor Asian Conference: Mechanisms and functions of non-apoptotic cell death.
  • Z.Y. Weng, F.Y. Tang, Y.F. Wang & H.W. Shyu. Lei-Gong Teng induces autophagy in non-small cell lung carcinoma cells. (2013), Cold Spring Harbor Asian Conference: Mechanisms and functions of non-apoptotic cell death.
研究計畫
  • 綠茶多酚EGCG誘導原發性滲出性淋巴瘤鐵依賴性細胞死亡分子機制之探討。2025高雄市立聯合醫院(共同主持人)
  • 綠茶多酚EGCG抑制阿斯匹靈所誘導人類疱疹病毒第八型溶解複製之研究。2024高雄市立聯合醫院(共同主持人)
  • 人類疱疹病毒第八型vBcl-2與鐵依賴性細胞死亡交互作用之研究。2023高雄市立聯合醫院(共同主持人)
  • 熱休克因子1 藉由影響m6A RNA修飾調控人類疱疹病毒第八型複製之研究。2022國科會(主持人)
  • 人類疱疹病毒第八型vBcl-2調控TLR4和發炎小體之研究。2022高雄市立聯合醫院(共同主持人)
  • Effects of aspirin on epigenetic regulation in human herpesvirus harboring primary effusion lymphoma cells. 2021高雄榮民總醫院 (共同主持人)
  • Study on the prevalence of nonhemolytic and nonpigmented group B Streptococci in southern Taiwan 2020 輔英科大附設醫院(共同主持人)
  • Effects of aspirin on human herpesvirus 8 harboring primary effusion lymphoma cells. 2020 高雄榮民總醫院 (共同主持人)
  • Effects of aspirin on human herpesvirus 8 harboring primary effusion lymphoma cells. 2019 高雄榮民總醫院 (共同主持人)
  • Role of Heat Shock factor 1 on human herpesvirus 8 Infection and virus induced metabolic perturbation. (MOST 106-2320-B-242-001) 2017科技部(主持人)
  • Effects of human herpesvirus 8 vBcl-2 on endoplasmic reticulum stress and heme oxygenase-1. 2018 高雄市立聯合醫院(共同主持人)
  • Study on EGCG induced cell senescence and metabolic perturbation in primary effusion lymphoma cells. 2017 高雄市立聯合醫院(共同主持人)
  • Study on Resveratrol induced cell senescence and metabolic perturbation in primary effusion lymphoma cells. 2016 (RG16014) 阮綜合醫院 (共同主持人)
  • Effects of resveratrol on the human herpesvirus 8 microRNA expression in primary effusion lymphoma cell. (RG15-012) 2015阮綜合醫院(共同主持人)
  • The effects of advanced glycation end products on human herpevirus 8 replication,, 2015 天主教聖功醫療財團法人聖功醫院 (共同主持人)
  • Study on Resveratrol induced cell death in the human herpesvirus 8 harboring PEL cells. (RG13-005) 2013阮綜合醫院 (共同主持人)
  • The effects of human herpesvirus 8 encoded vFLIP on ER stress and autophagy. (NSC 100-2320-B-242 -002) 2011 科技部(主持人)
  • The effects of human herpesvirus 8 encoded vFLIP on cells and the cellular genes (NSC 97-2320-B-242 -003 -MY3) 2008-2011 科技部(主持人)
榮譽事蹟
  • 107學年度第一學期輔英科技大學教學評量績優課程(微生物學)
  • 107、108、109學年度輔英科技大學績優導師
  • 2024年全國三分鐘生科論文口說競賽南區預賽特優(林芳羽)指導老師
  • 113學年度 學生醫技研究方法成果競賽第一名 (林芳羽) 指導老師
  • 112學年度 學生醫技研究方法成果競賽第二名 (施佳妤) 指導老師
  • 111學年度 學生醫技研究方法成果競賽第二名 (胡嘉真) 指導老師
  • 110學年度 學生醫技研究方法成果競賽佳作(蔡品儀) 指導老師
  • 109學年度 學生醫技研究方法成果競賽第二名 (葉于瑄) 指導老師佳作(梁珈瑀)
  • 109學年度輔英科技大學績優導師
  • 108學年度輔英科技大學績優導師
  • 107學年度輔英科技大學績優導師
  • 107學年度輔英科技大學績優導師
  • 107學年度第一學期輔英科技大學教學評量績優課程 (微生物學)
  • 107學年度 學生醫技研究方法成果競賽第三名 (黃子凌) 指導老師佳作(林潔如)
  • 106學年度 學生醫技研究方法成果競賽第二名 (葉玲君) 指導老師
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